Dr. Marco Manfredini


Si è laureato in Medicina e Chirurgia presso l’Università di Modena e Reggio Emilia in data 20/07/10, discutendo la tesi dal titolo “Caratterizzazione morfologica in vivo e valutazione dei pathways attivati nel melanoma: proposta di una nuova classificazione”, relatore Prof. Giovanni Pellacani, con valutazione 110/110 e lode.

Ha superato l’esame di stato per l’abilitazione professionale, con iscrizione all’albo dei medici di Mantova, Numero di matricola: 2994, in data 14/02/11.

Dal 2011 al 2012 è stato assegnista di ricerca per il progetto europeo SKINSPECTION – Multimodal Inspection of the skin with a method of hybrid imaging, acoustics and optics, presso l’Università di Modena
e Reggio Emilia.

Dal 2014 ha utilizzato i principali laser ablativi e non ablativi di tipo dermatologico (CO2, PDL,
Alessandrite, Nd:Yag, Q-Switched).

In data 03/07/17 si è specializzato in Dermatologia e Venereologia, discutendo la tesi dal titolo “Acne:
morphologic and vascular study of lesions and surrounding skin by means of optical coherence
tomography”, relatore Prof. Giovanni Pellacani, valutazione 110/110 e lode.

E’ stato Visiting student presso numerosi istituti di ricerca nazionali e internazionali, in particolare: Cancer cell Laboratory, Thomas Jefferson University (Philadelphia, PA); St. John’s Institute of Dermatology, St. Thomas’ Hospital (London, UK); Di Nardo Laboratory, Dermatology Unit, University of California San Diego (San Diego, CA).

Principali interessi e attività di ricerca:

  • Diagnosi non invasiva dei tumori cutanei e delle patologie infiammatorie mediante dermoscopia,
    microscopia confocale a riflettenza (RCM) e tomografia a coerenza ottica (OCT).
  • Studio di acne e patologie correlate.
  • Studio di idrosadenite suppurativa e patologie correlate.
  • Studio di sindromi genetiche e genodermatosi.
  • Utilizzo di laser ablativi e non ablativi di tipo dermatologico.

Pubblicazioni:

1. C. Longo, E. Moscarella, P. Pepe, A.M. Cesinaro, A. Casari, M. Manfredini, I. Stanganelli, S. Gardini, C. Cota, G. Argenziano, G. Pellacani and I. Zalaudek. “Confocal microscopy of recurrent naevi and recurrent melanomas: a retrospective morphologic study”, Br J Dermatol. 2011 Jul;165(1):61-8.
2. Seidenari S, Arginelli F, Bassoli S, Cautela J, Cesinaro A M, Guanti M, Guardoli D, Magnoni C, Manfredini M, Ponti Giovanni, König K. “Diagnosis of BCC by multiphoton laser tomography”. Skin Res Technol. 2013 Feb;19(1):e297-304..
3. Seidenari S, Arginelli F, Manfredini M; “Multiphoton laser microscopy with fluorescence lifetime imaging and skin cancer.” In: Baldi A, Spugnini E P, and Pasquali P. “Skin Cancer: A Practical Approach”. Springer-Verlag. 2013
4. Seidenari S, Arginelli F, Dunsby C, French P, König K, Magnoni C, Manfredini M, Talbot C, Ponti G. Multiphoton laser tomography and fluorescence lifetime imaging of basal cell carcinoma: morphologic features for non-invasive diagnostics. Exp Dermatol. 2012 Nov;21(11):831-6. doi:10.1111/j.1600-0625.2012.01554.x. Epub 2012 Aug 7.
5. Manfredini M , Arginelli F, Dunsby C, French P, Talbot C, König K, Pellacani G, Ponti G, Seidenari S. “High-resolution imaging of basal cell carcinoma: a comparison between multiphoton microscopy with fluorescence lifetime imaging and reflectance confocal microscopy” Skin Res Technol. 2013 Feb;19(1):e433-43. doi: 10.1111/j.1600-0846.2012.00661.x. Epub 2012 Sep 12.
6. Arginelli F, Manfredini M, Bassoli S, Dunsby C, French P, König K, Magnoni C, Ponti G, Talbot C, Seidenari S. High resolution diagnosis of common nevi by multiphoton laser tomography and fluorescence lifetime imaging. Skin Res Technol. 2012 Dec 29. doi: 10.1111/srt.12035. [Epub ahead of print]
7. Manfredini M, Mazzaglia G, Ciardo S, Simonazzi S, Farnetani F, Longo C, Pellicani G. Does skin hydration influence keratinocyte biology? In vivo evaluation of microscopic skin changes induced by moisturizers by means of Reflectance Confocal Microscopy. Skin Res Technol. 2013 Feb 26. doi:10.1111/srt.12042.
8. Ponti G, Meschieri A, Pollio A, Ruini C, Manfredini M, Longo C, Mandel VD, Ciardo S, Tomasi A, Giannetti L, Pellacani G. Fordyce granules and hyperplastic mucosal sebaceous glands as distinctive stigmata in Muir-Torre syndrome patients: characterization with reflectance confocal microscopy. J Oral Pathol Med. 2014 Sep 12.
9. Manfredini M, Mazzaglia G, Ciardo S, Farnetani F, Mandel VD, Longo C, Zauli S, Bettoli V, Virgili A, Pellacani G. Acne: in vivo morphologic study of lesions and surrounding skin by means of reflectance confocal microscopy. J Eur Acad Dermatol Venereol. 2015 May;29(5):933-9.
10. Ponti G, Manfredini M, Tomasi A, Pellacani G. Distinctive clinical and dermoscopic features of BRAF V600K mutated melanomas. Br J Dermatol. 2015;172(5):1438-40.
11. Ruini C, Manfredini M, Pellacani G, Mandel VD, Tomasi A, Ponti G. Confocal microscopy characterization of BRAFV600E mutated melanomas. Melanoma Res. 2015 Aug;25(4):367-71.
12. Ponti G, Manfredini M, Tomasi A, Pellacani G. Muir-Torre Syndrome and founder mismatch repair gene mutations: A long gone historical genetic challenge. Gene. 2015 Jul 2. pii: S0378-1119(15)00802-1.
13. Reggiani C, Manfredini M, Mandel VD, Farnetani F, Ciardo S, Bassoli S, Casari A, Guida S, Argenziano G, Lallas A, Ulrich M, Pellacani G, Longo C. Update on non-invasive imaging techniques in early diagnosis of non-melanoma skin cancer. G Ital Dermatol Venereol. 2015 Aug;150(4):393-405.
14. Farnetani F, Manfredini M, Mandel VD, Ponti G. Giuseppe Mariani: the Biography on the fiftieth anniversary of his death. G Ital Dermatol Venereol. 2015 Oct;150(5):638-9.
15. Farnetani F, Manfredini M, Mandel VD, Ponti G. Leonardo Martinotti: the biography on the fiftieth anniversary of his death. G Ital Dermatol Venereol. 2015 Dec;150(6):768-9.
16. Mandel VD, Ferrari B, Manfredini M, Giusti F, Pellacani G. Annually recurring erythema annulare centrifugum: a case report. J Med Case Rep. 2015 Oct 22;9:236. doi: 10.1186/s13256-015- 0718-1.
17. Guida S, Longo C, Casari A, Ciardo S, Manfredini M, Reggiani C, Pellacani G, Farnetani F. Update on the use of confocal microscopy in melanoma and non-melanoma skin cancer. G Ital Dermatol Venereol. 2015 Oct;150(5):547-63. Epub 2015 Jul 3.
18. Farnetani F, Scope A, Braun RP, Gonzalez S, Guitera P, Malvehy J, Manfredini M, Marghoob AA, Moscarella E, Oliviero M, Puig S, Rabinovitz HS, Stanganelli I, Longo C, Malagoli C, Vinceti M, Pellacani G. Skin Cancer Diagnosis With Reflectance Confocal Microscopy: Reproducibility of Feature Recognition and Accuracy of Diagnosis. JAMA Dermatol. 2015 Oct;151(10):1075-80.
19. Ponti G, Tomasi A, Manfredini M, Pellacani G. Oral mucosal stigmata in hereditary-cancer syndromes: From germline mutations to distinctive clinical phenotypes and tailored therapies. Gene. 2016 May 10;582(1):23-32.
20. Ponti G, Pellacani G, Tomasi A, Sammaria G, Manfredini M. Skeletal stigmata as keys to access to the composite and ancient Gorlin-Goltz syndrome history: The Egypt, Pompeii and Herculaneum lessons. Gene. 2016 Sep 10;589(2):104-11.
21. Mandel VD, Farnetani F, Vaschieri C, Manfredini M, Cesinaro AM, Giusti F, Pellacani G. Pemphigus with features of both vulgaris and foliaceus variants localized to the nose. J Dermatol2016 Aug;43(8):940-3.
22. Ponti G, Manfredini M, Pellacani G, Tomasi A. Role of microsatellite instability, immunohistochemistry and mismatch repair germline aberrations in immunosuppressed transplant patients: a phenocopy dilemma in Muir-Torre syndrome. Clin Chem Lab Med. 2016 Nov 1;54(11):1725-1731.
23. Ponti G, Manfredini M, Ruini C. Wall paintings facies and their possible genetic correlates in the
ancient Pompeii: A bio-anthropologic message from the past? Gene. 2016 Sep 10;589(2):151-6.
24. Manfredini M, Greco M, Farnetani F, Mazzaglia G, Ciardo S, Bettoli V, Virgili A, Pellacani G. In vivo monitoring of topical therapy for acne with reflectance confocal microscopy. Skin Res Technol. 2016 Jun 8. doi: 10.1111/srt.12298.
25. Manfredini M, Pellacani G, Losi L, Maccaferri M, Tomasi A, Ponti G. Desmoplastic melanoma: a challenge for the oncologist. Future Oncol. 2017 Feb;13(4):337-345.
26. Gibellini L, De Biasi S, Bianchini E, Bartolomeo R, Fabiano A, Manfredini M, Ferrari F, Albertini G, Trenti T, Nasi M, Pinti M, Iannone A, Salvarani C, Cossarizza A, Pellacani G. Anti-TNF-α Drugs Differently Affect the TNFα-sTNFR System and Monocyte Subsets in Patients with Psoriasis. PLoS One. 2016 Dec 9;11(12):e0167757.
27. Manfredini M, Greco M, Farnetani F, Ciardo S, De Carvalho N, Mandel VD, Starace M, Pellacani G. Acne: morphologic and vascular study of lesions and surrounding skin by means of optical coherence tomography. J Eur Acad Dermatol Venereol. 2017 May 30.
28. Magnoni C, Manfredini M, Pellacani G; Surgical approach, reconstructive techniques and post surgical wound care in hidradenitis suppurativa, G Ital Dermatol Venereol; accepted for publication
29. Manfredini M, Longo C, Ferrari B, Piana S, Benati E, Casari A, Pellacani G, Moscarella E; Dermoscopic and reflectance confocal microscopy features of cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol, 2017, Jul 11 [Epub ahead of print].

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